GABA is the main inhibitory neurotransmitter in the mature brain. Many cognitive pathologies (Autism, ADD, ADHD, Anxiety Disorder, Sensory Processing Disorder etc.) can be described mechanistically as incomplete GABA action at the neural synapse – leading to too strong a neural response to an input (sensory or otherwise). This perspective in the 2/7/2014 Science discusses GABA dysregulation in the context of the Oxytocin flood initiated in the mother during birth. The perspective is informative both as to the importance of natural birth for normal cognition, and as to the role of GABA in cognition.